Model of nuclear PKA microdomain

In the classical model of cAMP/PKA signaling, nuclear PKA signaling is thought to result from the gradual diffusion of activated PKA from the cytosol into the nucleus. However, our work indicates that the nucleus contains a resident pool of PKA holoenzyme, whose activity is tightly regulated through the formation of an AKAP-dependent signaling microdomain that contains both PKA holoenzyme and PDEs.